INTRODUCTION

The existence of heterophilic antibodies and their potential for causing interference in immunoassays has been known for many years.

The increasing use of the susceptible 2-site immunometric ("sandwich") assay format has led to growing concern over the problem, and because of this Scantibodies Laboratory has developed a unique heterophilic blocking reagent (HBR) that minimizes the occurrence of heterophilic antibody interference.

IN THIS BRIEF...

. Qualification Test for the Application of HBR
. Heterophilic Antibody Interference - What is It?
. The Unique Aspects of HBR over Conventional Blocking Methods
. Heterophilic Interference - What is Known?
. Heterophilic Antibodies - Sources
. Heterophilic Interference - How is it Detected?
. What is the Difference Between Heterophilic Antibody and HAMA?
. What is a Blocking Reagent?
. Characteristics of an Ideal Heterophilic Blocking Reagent
. The Scantibodies Heterophilic Blocking Reagent (HBR)
. Performance Characteristics
. False Positive Identification
. Availability